The Detroit Lions will play the San Francisco 49ers in the season's final Monday Night Football game. The Vikings' win in Week 17 made their matchup with Detroit in Week 18 an unofficial NFC North Championship Game. 

Since Minnesota won, tonight's Lions game has become meaningless. Even if the Lions lose tonight, the winner of next week's game between Detroit and Minnesota will win the NFC North Championship and the #1 seed. 

Dan Campbell has said starters are playing against the 49ers, but we aren't sure how long they'll be in the game. Therefore, we're avoiding Detroit's props and looking to San Francisco. 

The Lions' most significant weakness in the Cold, Hard Football Facts is their run game. They're 26th in Defensive Rusher Rating, one of the worst in the NFL. 

The 49ers' most significant weak spot this season has been running back because Christian McCaffrey and Jordan Mason suffered season-ending injuries. 

Isaac Guerendo will start for the 49ers, coming off 78 and 57-yard performances in his past two contests. His total is 60.5 tonight, and we're leaning over as he has received 15+ carries in the past two weeks. 

He is also very explosive and known for long carries, which has been apparent over the past three games. We're also taking Ricky Pearsall over 14.5 yards for his longest reception. 

The Lions are 19th in Defensive Real Passing Yards/Attempt. They have a ton of injuries, and they allow explosive plays through the air, which plays into Pearsall's strengths.